Understanding Vaccine Immunity: LMU Team Reveals How Dendritic Cells Process Yellow Fever Vaccine Virus
- Feb 27
- 2 min read
Yellow4FLAVI continues to gain recognition across Europe's scientific community. From February 4 to 6, Professor Anne Krug and Margarita Shnipova, PhD student, from Ludwig Maximilian University of Munich (LMU) played a central role at the annual meeting of the Dendritic Cell Working Group (AKDC) of the German Society of Immunology in Waischenfeld, Germany.
As one of the conference organizers, Prof. Krug facilitated networking opportunities while she presented with her PhD student two research posters showcasing Yellow4FLAVI's advances. The first poster, "RIG-I-like receptor-dependent type I Interferon regulates antigen dose and activation in yellow fever vaccine 17D infected antigen presenting cells," explores how innate immune sensors control vaccine responses. The second, "Defining entry and endocytosis of the yellow fever vaccine virus YF17D leading to antigen presentation by dendritic cells," investigates the critical mechanisms by which dendritic cells recognize, internalize, and present the vaccine virus to trigger immunity.
Just weeks earlier (January 29-31), Prof. Krug was invited to Amsterdam University Medical Center (UMC) where she delivered an invited talk, "Dendritic Cells and Type I Interferon Shape Yellow Fever Vaccine Efficacy," and led a masterclass on plasmacytoid dendritic cell identity, highlighting Yellow4FLAVI's published work and ongoing manuscripts.
In December, Prof. Krug presented the RIG-I receptor poster at the French Dendritic Cell Society (CFCD) meeting in Paris, followed by a visit to Yellow4FLAVI Coordinator Dr. Giovanna Barba-Spaeth from Institut Pasteur to strengthen collaborative ties.
These sustained dissemination activities underscore the project's growing impact.
Prof. Krug's appointment as speaker of the AKDC working group (advancing from co-speaker) reflects her internationally recognized expertise in dendritic cell immunology, a cornerstone of Yellow4FLAVI's research strategy.
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