Our project partners at KUM, IP, and LMU have published a new study examining how the state of our immune system before vaccination affects how we respond to the yellow fever 17D (YF17D) vaccine. The study looked at immune data from 250 healthy young individuals to uncover factors that influence vaccine effectiveness.
The study, led by Simon Rothenfusser (KUM) in collaboration with Giovanna Barba-Spaeth (IP) and Anne Krug (LMU), provides valuable insights how variation in the immune system influences vaccine effectiveness, guiding future personalized vaccination strategies.
Key Highlights:
✅ Sex and CMV Status Affect Baseline Immunity – While these factors clearly influence important cellular components of our basal immune system, they don't significantly influence how well we respond to theYF17D vaccine. (CMV stands for Cytomegalovirus, a common virus that can impact the immune system.)
✅ Pre-Existing Immune Activation Predicts Stronger Responses – People with higher levels of activatedCD4+ T cells (a type of immune cell) before the vaccine tend to have stronger vaccine responses.
✅ CXCL10 as a Negative Predictor – Higher baseline levels of CXCL10, a protein linked to inflammation, were associated with weaker vaccine responses.
✅ Environmental Factors Matter – External factors, like smoking and environment, can influence immune responses and vaccine effectiveness.
🔗 Read the full publication here: 10.1016/j.xcrm.2025.101946
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