KLINIKUM DER UNIVERSITAT MUNCHEN (KUM) LMU Affiliated Entity
Munich, Germany
Klinikum der Universität München (KUM) is one of Germany's leading medical centers, located in Munich. Renowned for its state-of-the-art facilities and cutting-edge research, KUM offers comprehensive medical care across various specialties. The hospital is affiliated with the Ludwig Maximilian University of Munich, ensuring a strong connection between patient care, research, and education. KUM is dedicated to providing high-quality healthcare services, advancing medical knowledge, and training the next generation of healthcare professionals.
At the Division of Clinical Pharmacology we are interested in basic principles that modulate innate and adaptive immune responses and can be used to make immunotherapeutic strategies against cancer and viral infections more effective. The research group of Dr. Rothenfusser focuses thereby on four topics: genetic and non-genetic factors that affect and predict individual responses to viral infections and vaccinations; sensing-mechanisms of viral infection by innate immunity; therapy of tumors with immunostimulatory nucleic acids, and the molecular understanding of primary immune deficiency syndromes.
Project Team
Project tasks
Work Package 2 Lead: Identification of host factors that predict and influence the vaccine response to YF17D
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Task 2.1. Lead: Recruiting and collecting samples from new European cohorts vaccinated with YF17D
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Task 2.3. Lead: Quantification and serological characterisation of the vaccine response to YF17D in the collected cohorts
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Task 2.4. Lead: Investigate host factors that predict and influence the vaccine response to YF17D
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Task 2.5. Serologically characterise cohorts exposed to WNV and Usutu Virus
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Task 2.6. Test factors hypothesised to influence the response to flaviviruses based on the analysed cohort data in animal models of flavivirus infection
Work Package 3 Long‐term protective memory response after vaccination
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Task 3.1. Analysis of number, phenotype, epitope-specificity and B cell receptor repertoire profile of YFV and TBE memory B cells
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Task 3.2. Lead: Cloning of neutralising antibodies and interrogation of binding sites
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Task 3.4. Phenotypic, metabolic and functional analysis of memory T cells