ImmuneWatch BV (IW)
Antwerp, Belgium
ImmuneWatch aims to accelerate the development of vaccines, therapeutics and diagnostics by truly understanding T-cell responses. ImmuneWatch’s machine learning platform, ImmuneWatch DETECT can annotate the epitope specificity of T-cell receptor (TCR) sequences, turning TCR repertoires into clinically actionable data. ImmuneWatch is a spin-off of the University of Antwerp and the University Hospital Antwerp, Belgium.
Within this project, ImmuneWatch will use its DESIGN and DETECT products to support the in-depth evaluation of T cell response against flaviviruses and flavivirus vaccines. DESIGN is a reverse vaccinology pipeline to identify immunogenic T cell epitopes in a pathogen sequence. DETECT can track TCRs specific for more than 1700 different epitopes, and new custom training for the project will be added to enable to track TCRs specific to flavivirus epitopes.
Project Team
Dr. Tom Bosschaerts
Tom is a co-founder of ImmuneWatch, as Operations Director his responsibilities include business development and grant and project management. Tom holds a PhD in Immunology and a master in Bio-Engineering Sciences from the University of Brussels.
Dr. Sander Wuyts
Sander is a co-founder of ImmuneWatch, and CEO of the company. His responsibilities include overall project oversight, R&D strategy and financial management. Sander holds a PhD in Bioinformatics and a master in Bio-Engineering Sciences from the University of Antwerp
Prof. Pieter Meysman
Pieter is an academic co-founder of ImmuneWatch and acting CTO of the company. He holds a position as Associate Professor in biomedical data sciences and leads a research group focused on immunoinformatics at the University of Antwerp. Pieter holds a PhD in Bioinformatics with focus on T cell receptor – epitope predictions, and a master in Bio-Engineering Sciences from the KU Leuven.
Max Van Houcke
Max is a data scientist at ImmuneWatch. Max holds a master in computer science and software engineering from the University of Antwerp.
Project tasks
Work Package 3 Long‐term protective memory response after vaccination
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Task 3.1. Analysis of number, phenotype, epitope-specificity and B cell receptor repertoire profile of YFV and TBE memory B cells
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Task 3.3. Identification of T cell epitope immunodominance of the memory compartment